I rarely mix weed and alcohol—otherwise, I become more silent than a hermit crab floating in space.
But pursuing the high that results from combining the two drugs—known as a "crossfade"—isn't uncommon. Researchers, however, are still delving into the science behind this blissed-out state of mind—and why so many people seek it out.
An English physician in 1870 reported on morphine's tendency to "encourage the very pain it pretends to relieve." Researchers found that active heroin users were more sensitive to pain than expected. Other investigators took note, and by decade's end, a half-dozen studies had demonstrated similar results among heroin users as well as among recovering users on methadone.
For many people who live with chronic pain, opioids can seem like the difference between a full life or one lived in agony. Over the past few decades, they have become go-to drugs for acute pain, but Dr. Erin Krebs, with the Minneapolis Veteran's Administration Health Care System and the University of Minnesota, says the science about the effectiveness of opioids for chronic, or long-term, pain has been lacking.
As the deadly crisis refuses to wane, cities search for unconventional responses to overdoses.
“It’s an important study, and it shows that the fentanyl test can be really used as a point-of-care test within harm-reduction programs,” says Jon Zibbell, a public health scientist at nonprofit research organization RTI International.
"Although there was an overall dampening effect of alcohol on the prefrontal cortex, even at a low dose of alcohol we observed a significant positive relationship between dorsomedial and dorsolateral prefrontal cortex activity and alcohol-related aggression," lead author Thomas Denson, from the University of New South Wales in Australia, said in a statement. "These regions may support different behaviors, such as peace versus aggression, depending on whether a person is sober or intoxicated.
The vaccine is built by binding a heroin molecule to a protein recognized by the immune system. The heroin molecule does not trigger an immune reaction on its own. When the vaccine initiates an immune response, antibodies are produced that bind to heroin molecules that build up when a person is using the drug. The antibody binding prevents the drug from reaching the brain and causing a high.
Recently, driven largely by opioid-related deaths—predominantly of our white sisters and brothers—President Donald Trump proclaimed that the opioid problem was now a national emergency. He vowed to “spend a lot of time, a lot of effort and a lot of money on the opioid crisis” because “it is a serious problem the likes of which we have never had.”
This is false. Beginning in the late 1960s, the heroin crisis played out in a similar fashion, except that the face of the heroin addict then in the media was black, destitute and engaged in repetitive petty crimes to feed his or her habit. One solution was to lock up users, especially after passage of New York State's infamous Rockefeller drug laws in 1973. By the early 2000s more than 90 percent of those convicted under those laws were black or Latino, far out of proportion to the fraction of users they represented.
WASHINGTON — U.S. health regulators on Tuesday asked makers of popular anti-diarrhea drugs to sell their medications in smaller amounts to make them harder to abuse.
The request comes amid a spike in overdoses from large doses of the over-the-counter drugs, which contain a small amount of an opioid.
The Food and Drug Administration wants manufacturers to package their medications in smaller quantities, such as eight tablets per package. Currently, some generic versions are sold in boxes of up to 200 tablets. The FDA said it also plans to ask online retailers to make it harder to order bulk amounts of the drugs.
Williamson, W.Va., sits right across the Tug Fork river from Kentucky. The town has sites dedicated to its coal mining heritage and the Hatfield and McCoy feud and countsjust about 3,000 residents.
But despite its small size, drug wholesalers sent more than 20.8 million prescription painkillers to the town from 2008 and 2015, according to an investigation by the House Committee on Energy and Commerce. The opioids — hydrocodone and oxycodone pills — were provided to two pharmacies just four blocks apart.
The treaties and laws governing how drugs are regulated by nations were, for the most part, written a half-century or more ago. And while the science surrounding drugs and drug use has advanced rapidly over that time, the laws have barely evolved.
As a result, there is little correlation between the dangers of various drugs and the stringency of laws regulating their use.
